People

Research Interests

Biomaterials, tailoring cell-material interfaces for drug delivery and tissue engineering applications; direct, quantitative measurement of biological interactions.

Current Research

The Biomimetic Materials Engineering Laboratory is focused on the development of biomaterials to probe how structure, material properties and composition of the cell-biomaterial interface affect fundamental cellular processes. Specifically, we are interested in developing substrata with features that mimic physiological and pathophysiological environments to study fundamental cellular processes at the biointerface. Current research projects include tissue engineering of small diameter blood vessels for bypass and intravascular pharmacology (e.g. stents); development of targeted nano- and micro-particle contrast agents for multi-modal (magnetic resonance, ultrasound, and optical) detection of atherosclerotic and vulnerable plaque; and engineering biomimetic systems to study restenosis and breast cancer.

Selected Recent Publications

Isenberg, B.C., Tsuda, Y., Williams, C., Shimizu, T., Yamato, M., Okano, T. and

Wong, J.Y. “A Thermoresponsive, Microtextured Substrate for Cell Sheet Engineering with Defined Structural Organization” Biomaterials 29(17): 2565-72 (2008)

Duncanson, W.J., Figa, M.A., Hallock, K., Zalipsky, S., Hamilton, J.A. and Wong, J.Y. “Targeted Binding of PLA Microparticles with Lipid-PEG-tethered Ligands” Biomaterials 28: 4991-4999 (2007)

Koester, S., Leach, J.B., Pfohl, T., and Wong, J.Y. “Visualization of Flow-Aligned Type I Collagen Self-Assembly in Tunable pH-Gradients” Langmuir 23: 357-359 (2007)

 

Gaudet, C., Marganski, W.A., Kim, S., Brown, C.T., Gunderia, V., Dembo, M. and Wong, J.Y. “Influence of Substratum Type I Collagen Concentration on Fibroblast Spreading, Motility and Contractility” Biophys. J. 85 (5): 3329-3335 (2003)